What routes makes Essential Oils effective in Aromatherapy? A current perspective study

Authors

  • Deysen Kerlla Fernandes Bezerra Girão Centro Universitário Christus – UNICHRISTUS

DOI:

https://doi.org/10.62435/2965-7253.bjhae.2024.bjhae13

Keywords:

Aromatherapy, Essential Oils, Administration Routes

Abstract

Aromatherapy, the therapeutic application of essential oils extracted from plants, has emerged as a prominent practice in complementary and alternative medicine. Essential oils, renowned for their aromatic compounds, are utilized in a variety of therapeutic modalities to enhance physical, emotional, and mental health. Understanding the administration routes of essential oils is crucial for maximizing their therapeutic potential and ensuring safety. The method of administration—whether inhalation, topical application, or ingestion—significantly influences the absorption, distribution, and efficacy of the bioactive compounds in essential oils. For instance, inhalation directly interacts with the olfactory system, potentially impacting mood and stress levels, while topical application facilitates localized effects and transdermal absorption, providing targeted therapeutic benefits. Ingestion, though less common, requires careful consideration due to the potent nature and potential toxicity of essential oils. This paper emphasizes the importance of selecting the appropriate administration route based on desired outcomes and safety considerations. It also explores the concept of synergy, where the interaction of multiple essential oil constituents can enhance therapeutic effects, exemplified by the compounds in lavender and eucalyptus oils. This study highlights the challenges in aromatherapy research, including the need for standardization, quality assurance, and rigorous methodological approaches to validate the therapeutic efficacy of essential oils.

Author Biography

Deysen Kerlla Fernandes Bezerra Girão, Centro Universitário Christus – UNICHRISTUS

Centro Universitário Christus – UNICHRISTUS, Fortaleza, Ceará, Brazil.

References

Brennan SE, McDonald S, Murano M, McKenzie JE. Effectiveness of aromatherapy for prevention or treatment of disease, medical or preclinical conditions, and injury: protocol for a systematic review and meta-analysis. Syst Rev. 2022 Jul 26;11(1):148. doi: 10.1186/s13643-022-02015-1. PMID: 35883155; PMCID: PMC9317467.

Bjørklund G, Shanaida M, Lysiuk R, Butnariu M, Peana M, Sarac I, Strus O, Smetanina K, Chirumbolo S. Natural Compounds and Products from an Anti-Aging Perspective. Molecules. 2022 Oct 20;27(20):7084. doi: 10.3390/molecules27207084. PMID: 36296673; PMCID: PMC9610014.

Bunse M, Daniels R, Gründemann C, Heilmann J, Kammerer DR, Keusgen M, Lindequist U, Melzig MF, Morlock GE, Schulz H, Schweiggert R, Simon M, Stintzing FC, Wink M. Essential Oils as Multicomponent Mixtures and Their Potential for Human Health and Well-Being. Front Pharmacol. 2022 Aug 24;13:956541. doi: 10.3389/fphar.2022.956541. PMID: 36091825; PMCID: PMC9449585.

Cimino C, Maurel OM, Musumeci T, Bonaccorso A, Drago F, Souto EMB, Pignatello R, Carbone C. Essential Oils: Pharma-ceutical Applications and Encapsulation Strategies into Lipid-Based Delivery Systems. Pharmaceutics. 2021 Mar 3;13(3):327. doi: 10.3390/pharmaceutics13030327. PMID: 33802570; PMCID: PMC8001530.

Cui J, Li M, Wei Y, Li H, He X, Yang Q, Li Z, Duan J, Wu Z, Chen Q, Chen B, Li G, Ming X, Xiong L, Qin D. Inhalation Aro-matherapy via Brain-Targeted Nasal Delivery: Natural Volatiles or Essential Oils on Mood Disorders. Front Pharmacol. 2022 Apr 12;13:860043. doi: 10.3389/fphar.2022.860043. PMID: 35496310; PMCID: PMC9041268.

Lin TK, Zhong L, Santiago JL. Anti-Inflammatory and Skin Barrier Repair Effects of Topical Application of Some Plant Oils. Int J Mol Sci. 2017 Dec 27;19(1):70. doi: 10.3390/ijms19010070. PMID: 29280987; PMCID: PMC5796020.

Sadgrove NJ, Padilla-González GF, Leuner O, Melnikovova I, Fernandez-Cusimamani E. Pharmacology of Natural Volatiles and Essential Oils in Food, Therapy, and Disease Prophylaxis. Front Pharmacol. 2021 Oct 21;12:740302. doi: 10.3389/fphar.2021.740302. PMID: 34744723; PMCID: PMC8566702.

Koyama S, Heinbockel T. The Effects of Essential Oils and Terpenes in Relation to Their Routes of Intake and Application. Int J Mol Sci. 2020 Feb 25;21(5):1558. doi: 10.3390/ijms21051558. PMID: 32106479; PMCID: PMC7084246.

Sattayakhom A, Wichit S, Koomhin P. The Effects of Essential Oils on the Nervous System: A Scoping Review. Molecules. 2023 Apr 27;28(9):3771. doi: 10.3390/molecules28093771. PMID: 37175176; PMCID: PMC10180368.

Souto EB, Fangueiro JF, Fernandes AR, Cano A, Sanchez-Lopez E, Garcia ML, Severino P, Paganelli MO, Chaud MV, Silva AM. Physicochemical and biopharmaceutical aspects influencing skin permeation and role of SLN and NLC for skin drug delivery. Heliyon. 2022 Feb 11;8(2):e08938. doi: 10.1016/j.heliyon.2022.e08938. PMID: 35198788; PMCID: PMC8851252.

Raina N, Rani R, Thakur VK, Gupta M. New Insights in Topical Drug Delivery for Skin Disorders: From a Nanotechnological Perspective. ACS Omega. 2023 May 19;8(22):19145-19167. doi: 10.1021/acsomega.2c08016. PMID: 37305231; PMCID: PMC10249123.

Liaqat I, Riaz N, Saleem QU, Tahir HM, Arshad M, Arshad N. Toxicological Evaluation of Essential Oils from Some Plants of Rutaceae Family. Evid Based Complement Alternat Med. 2018 May 6;2018:4394687. doi: 10.1155/2018/4394687. PMID: 29853952; PMCID: PMC5960565.

Synergy can occur when multiple constituents interact to enhance each other's properties, leading to more pronounced therapeutic benefits. For example, some essential oils may combine anti-inflammatory, analgesic, and antispasmodic con-stituents, which together could provide a more substantial relief in conditions like muscle pain or inflammation than any single constituent could alone.

Caesar LK, Cech NB. Synergy and antagonism in natural product extracts: when 1 + 1 does not equal 2. Nat Prod Rep. 2019 Jun 19;36(6):869-888. doi: 10.1039/c9np00011a. PMID: 31187844; PMCID: PMC6820002.

Białoń M, Krzyśko-Łupicka T, Nowakowska-Bogdan E, Wieczorek PP. Chemical Composition of Two Different Lavender Essential Oils and Their Effect on Facial Skin Microbiota. Molecules. 2019 Sep 8;24(18):3270. doi: 10.3390/molecules24183270. PMID: 31500359; PMCID: PMC6767019.

Batiha GE, Teibo JO, Wasef L, Shaheen HM, Akomolafe AP, Teibo TKA, Al-Kuraishy HM, Al-Garbeeb AI, Alexiou A, Papadakis M. A review of the bioactive components and pharmacological properties of Lavandula species. Naunyn Schmiedebergs Arch Pharmacol. 2023 May;396(5):877-900. doi: 10.1007/s00210-023-02392-x. Epub 2023 Feb 11. PMID: 36773055; PMCID: PMC10079719.

Salvatori ES, Morgan LV, Ferrarini S, Zilli GAL, Rosina A, Almeida MOP, Hackbart HCS, Rezende RS, Albeny-Simões D, Oliveira JV, Gasparetto A, Müller LG, Dal Magro J. Anti-Inflammatory and Antimicrobial Effects of Eucalyptus spp. Essential Oils: A Potential Valuable Use for an Industry Byproduct. Evid Based Complement Alternat Med. 2023 Jun 28;2023:2582698. doi: 10.1155/2023/2582698. PMID: 37416804; PMCID: PMC10322318.

Arooj B, Asghar S, Saleem M, Khalid SH, Asif M, Chohan T, Khan IU, Zubair HM, Yaseen HS. Anti-inflammatory mechanisms of eucalyptol rich Eucalyptus globulus essential oil alone and in combination with flurbiprofen. Inflammopharmacology. 2023 Aug;31(4):1849-1862. doi: 10.1007/s10787-023-01237-6. Epub 2023 May 14. PMID: 37179510; PMCID: PMC10183087.

Pezantes-Orellana C, German Bermúdez F, Matías De la Cruz C, Montalvo JL, Orellana-Manzano A. Essential oils: a systematic review on revolutionizing health, nutrition, and omics for optimal well-being. Front Med (Lausanne). 2024 Feb 16;11:1337785. doi: 10.3389/fmed.2024.1337785. PMID: 38435393; PMCID: PMC10905622.

Monaghan TF, Agudelo CW, Rahman SN, Wein AJ, Lazar JM, Everaert K, Dmochowski RR. Blinding in Clinical Trials: Seeing the Big Picture. Medicina (Kaunas). 2021 Jun 24;57(7):647. doi: 10.3390/medicina57070647. PMID: 34202486; PMCID: PMC8308085.

Ali S, Ekbbal R, Salar S, Yasheshwar, Ali SA, Jaiswal AK, Singh M, Yadav DK, Kumar S, Gaurav. Quality Standards and Pharmacological Interventions of Natural Oils: Current Scenario and Future Perspectives. ACS Omega. 2023 Oct 17;8(43):39945-39963. doi: 10.1021/acsomega.3c05241. PMID: 37953833; PMCID: PMC10635672.

Khan MH, Dar NA, Alie BA, Dar SA, Lone AA, Mir GH, Fayaz U, Ali S, Tyagi A, El-Sheikh MA, Alansi S. Unraveling the Variability of Essential Oil Composition in Different Accessions of Bunium persicum Collected from Different Temperate Micro-Climates. Molecules. 2023 Mar 6;28(5):2404. doi: 10.3390/molecules28052404. PMID: 36903647; PMCID: PMC10005284.

Capetti F, Marengo A, Cagliero C, Liberto E, Bicchi C, Rubiolo P, Sgorbini B. Adulteration of Essential Oils: A Multitask Issue for Quality Control. Three Case Studies: Lavandula angustifolia Mill., Citrus limon (L.) Osbeck and Melaleuca alternifolia (Maiden & Betche) Cheel. Molecules. 2021 Sep 16;26(18):5610. doi: 10.3390/molecules26185610. PMID: 34577081; PMCID: PMC8471154.

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Published

2024-04-29